ReWRAP: Phase 2 found no statistically significant improvement in the study's measures of myelin repair

Worth knowing

In ReWRAP, bazedoxifene was generally well tolerated. However, it did not show a clear improvement in either the main MRI measure of myelin or the study's other measures of whether the treatment worked.

What this means for people with MS

Another drug with strong results in laboratory and animal research did not show a clear sign of myelin repair in people in Phase 2.

What kind of evidence exists?: ACTRIMS 2026 • completed study with participants assigned at random
How reliable is this source?: High • completed trial registry plus ACTRIMS presentation

ClinicalTrials.govRead the source ↗

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